ASLab · Computational Biology · IMSc Chennai

EXPLORING CHALLENGES IN LIFE & HEALTH SCIENCES THROUGH DATA & COMPUTATION

We study complex biological systems through the lens of computation, mathematics, and data. Our work brings together large-scale biological data curation, network and systems modelling, topology, and computational analysis to investigate questions ranging from environmental exposures and One Health to natural products, gene regulation, metabolism, and microbial systems. Across these diverse problems, we develop computational resources and mathematical approaches that reveal patterns, mechanisms, and connections within biology.

Trajectory Map
  1. CuttackBorn
  2. Kodarma2 years
  3. Delhi1989
  4. LeipzigMay 2008
  5. OrsayMarch 2010
  6. SeattleFebruary 2012
  7. TriesteMarch 2013
  8. India2014

I was born in Cuttack, Odisha, India and spent my first 7 years in a small industrial township Joda in Odisha. With my parents, I then moved to Kodarma in Jharkhand (formerly Bihar) for 2 years. In 1989, I moved to Delhi with my parents and settled there for next 20 years. In Delhi, I completed my Schooling, Bachelors, Masters and PhD. In May 2008, I moved to Leipzig, Germany for my Postdoctoral work. In March 2010, I shifted my base to Orsay (suburb of Paris). Between, March 2010 and February 2012, I kept shuttling between Paris and Leipzig. In February 2012, I moved to Seattle, USA. In March 2013, I moved to Trieste, Italy to continue my research. I returned to India in 2014.

Recent News

Data tool decodes ‘hallmarks’ of ageing

Featured in The Hindu BusinessLine

AgingHallmarksDB brings together 3,111 genes associated with the 11 hallmarks of ageing in an integrated resource, helping researchers explore how the biological processes underlying ageing are connected.

MEDIA COVERAGE

October 19, 2026

Free database ‘shows’ how drivers of ageing team up

Featured in The Hindu – Science

Researchers from institutes in Chennai and Mumbai have developed AgingHallmarksDB, a free database that brings together 3,111 genes associated with the 11 major hallmarks of ageing. The platform helps researchers and the public visualise how these complex biological processes connect.

MEDIA COVERAGE

October 18, 2026

New Database Maps 3,111 Genes Across the 11 Hallmarks of Aging

By Beatrice Stafford in Scienmag

AgingHallmarksDB integrates 3,111 aging-associated genes across the 11 hallmarks of aging, providing a systems-level resource to study hallmark relationships, disease associations and aging biology.

MEDIA COVERAGE

October 7, 2026

Cell Reports Sustainability Q&A

Shreyes Madgaonkar, along with our collaborator from NCCR, Chennai, Krishna Venkatarama Sharma, participated in a Q&A for Cell Reports Sustainability discussing our recently published work on chemicals used in aquaculture.

MEDIA COVERAGE

October 2, 2026

Researchers develop database to track aquaculture chemicals in Chennai

By U Tejonmayam in The Times of India

ReCAnt (Resource on Chemicals used in Aquaculture and their Ecotoxicity), developed at the Institute of Mathematical Sciences (IMSc), in collaboration with the National Centre for Coastal Research (NCR), brings together information on 690 chemicals reported in aquaculture.

MEDIA COVERAGE

September 19, 2026

First Prize for Oral Presentation to Nikhil Chivukula at IndiBioCom-2026

SRM Institute of Science and Technology, Tamil Nadu, India

First Prize for Oral Presentation at the Indian Conference on Bioinformatics and Computaional Biology (IndiBioCom) - 2026, SRM Institute of Science and Technology.

AWARD

September 9, 2026

Fish farms use way more chemicals than regulators have on their radar

By Sahana Ghosh in Nature India

A new database finds agencies document only a fraction of the chemicals used in aquaculture globally.

MEDIA COVERAGE

August 18, 2026

Something fishy in water bodies

By Manupriya in IIT Madras Shaastra

A new study, published in Cell Reports Sustainability, describes a database that compiles 690 such chemicals used globally. Called ReCAnt (Resource on Chemicals used in Aquaculture and their Ecotoxicity), the database was developed by The Institute of Mathematical Sciences (IMSc) and the National Centre for Coastal Research, both based in Chennai.

MEDIA COVERAGE

August 17, 2026

Best Poster Award to Rahul Tiwari at the RISE for Healthy Aging conference-2026

IISc, Bengaluru, India

Best Poster Award at the RISE for Healthy Aging conference, Indian Institute of Science, Bengaluru.

AWARD

August 6-7, 2026

Best Project Award to Jaisubasri Karthikeyan at PSG Tech

Jaisubasri Karthikeyan was awarded Best Project Award at the PSG Tech Alumni Association Annual General Body Meeting 2026, Coimbatore, for the co-first-authored publication "Benchmarking Artificial Intelligence Models for Predicting Nuclear Receptor Activity from Tox21 Assays", based on research conducted at IMSc, Chennai.

AWARD

July 2, 2026

Full travel award to Madhumita Mondal at BCMLS-2026

Madhumita Mondal received a full travel award to deliver a talk at the 2nd Bonn Conference on Mathematical Life Sciences (BCMLS), University of Bonn, Germany.

AWARD

March 16-19, 2026,

How do ‘natural polypills’ work?

By K Bharat Kumar in The Hindu Business Line

A computational approach to decoding ayurvedic medicine

MEDIA COVERAGE

March 9, 2026

Best Poster Award to Shreyes Rajan Madgaonkar at WOSC-2026

CSIR-NIO, Goa, India

Shreyes Rajan Madgaonkar was awarded Best Poster Prize under the theme "Ocean Health" at the World Ocean Science Congress (WOSC) - 2026, CSIR-NIO.

AWARD

February 26, 2026

Mapping Brain Connectivity Changes

Apple Podcasts

This research study utilizes topological data analysis (TDA) to examine how brain functional connectivity changes during healthy aging and in individuals with autism spectrum disorder (ASD).

PAPER TALK

February 7, 2026

How the brain's wiring changes

By Sahana Ghosh in Nature India

A mathematical tool offers a closer look at brain architecture for improved therapies

MEDIA COVERAGE

January 22, 2026

Mathematics Reveals Brain Changes

By Jana Gregor in Max Planck Society News

Introduces a novel mathematical approach that enables identification of specific brain regions whose connectivity shifts with age or differs in autism spectrum disorder (ASD).

MEDIA COVERAGE

January 6, 2026

Microplastics laden with toxins and pathogens fill India’s marketplace air

By Sahana Ghosh in Nature India

Researchers warn of a “Trojan horse” effect as plastic particles small enough to inhale carry carcinogens and microbes into the lungs.

MEDIA COVERAGE

November 12, 2025

HBNI Outstanding Doctoral Student Award 2025 in Life Sciences to Ajaya Kumar Sahoo

Ajaya Kumar Sahoo received the HBNI Outstanding Doctoral Student Award 2025 in Life Sciences across HBNI CIs, for his PhD research.

AWARD

June 2, 2025

Shining light on the potential biomarkers of UV exposure

By Bharti Dharapuram in IMSc Newsletter March, 2025

MEDIA COVERAGE

May 30, 2025

Computational tools reveal ecological effects of pervasive pollutants

By Bharti Dharapuram in IMSc Newsletter March, 2025

MEDIA COVERAGE

March, 2025

Flash Talk Award to Priyotosh Sil at 47th Indian Biophysical Society Meeting

Priyotosh Sil received a Flash Talk award of ₹5,000 at IBS 2025 hosted by IIT Madras, Chennai.

AWARD

March 9, 2025

Best Poster Award to Shreyes Rajan Madgaonkar at MPRISM 2025

IISER Kolkata, India

Shreyes Rajan Madgaonkar was awarded Best Poster Prize at the International Conference on Microplastic Research Innovation & Sustainable Management (MPRISM), IISER Kolkata.

AWARD

February 16, 2025

Using maths to identify health risks from plastics

By Subha Priyadarshini in Nature India

Mathematical approaches to identify health risks from plastic materials and compounds.

MEDIA COVERAGE

January, 2025

Travel Award to Priyotosh Sil at European Conference on Mathematical and Theoretical Biology

Toledo, Spain

Priyotosh Sil received a €350 travel award to attend the European Conference on Mathematical and Theoretical Biology, Toledo, Spain.

AWARD

July 26, 2024

Raman-Charpak Fellowship to Priyotosh Sil at IFCPAR/CEFIPRA

Université Paris-Saclay, France

Priyotosh Sil was awarded by IFCPAR/CEFIPRA to visit Université Paris-Saclay, France, for 3 months.

AWARD

May, 2024

Best Poster Award to Shanmuga Priya B at ICB-HFS 2024

Pondicherry University, India

Shanmuga Priya B was awarded Best Poster Prize at the International Conference on Bioinformatics in Health and Food Security (ICB-HFS), Pondicherry University.

AWARD

February 16, 2024

Best Poster Award to Nikhil Chivukula at AIBC 2024

Faridabad, India

Nikhil Chivukula was awarded Best Poster Prize at the 17th Annual International Biocuration Conference (AIBC), Faridabad, India.

AWARD

March 8, 2024

HBNI Outstanding Doctoral Student Award 2023 in Life Sciences to Janani R

Janani R received the HBNI Outstanding Doctoral Student Award 2023 in Life Sciences across all HBNI CIs, for her PhD research.

AWARD

June 3, 2023

Best Poster Award to Yasharth Yadav at CNSD-2022

IISER Pune, India

Yasharth Yadav won Best Poster Prize at the Conference on Nonlinear Systems and Dynamics (CNSD), IISER Pune, with €200 prize and open-access publication invitation from EuroPhysics Letters.

AWARD

December 18, 2022

Medicinal fungi may be suitable for identifying novel drugs

By Shubashree Desikan in The Hindu October 2, 2022

MEDIA COVERAGE

October 2, 2022

Best Poster Award to Ajaya Kumar Sahoo at HBNI Theme Meeting on Life Sciences

Ajaya Kumar Sahoo was awarded the Best Poster Prize at the HBNI Theme Meeting on Life Sciences, held at RRCAT, Indore.

AWARD

September 10, 2022

ANSES relies on DEDuCT to establish a list of endocrine disruptors

ANSES, France

French Agency for Food, Environmental and Occupational Health & Safety (ANSES), as part of the second national strategy on endocrine disruptors (SNPE2) of France, has relied on our methodology and resource DEDuCT to establish a list of substances of interest.

By ANSES in Accelerating the assessment of endocrine disruptors April 15, 2021

POLICY

April 15, 2021

Indian team expands database of potenial endocrine disrupting chemicals

By Emma Davies ChemicalWatch

Indian researchers have updated and expanded a database of scientific studies on endocrine disrupting chemicals (EDCs), which was developed primarily as a tool to aid regulatory risk assessment. By Emma Davies in ChemicalWatch December 8, 2020

MEDIA COVERAGE

December 8, 2020

Poster Prize to B.S. Karthikeyan at India International Science Festival (IISF) 2019

India International Science Festival, Kolkata

B.S. Karthikeyan, Research Associate in the group, presented a poster on our work on endocrine disruptors at the Young Scientists Conference (YSC), IISF 2019 held in Kolkata. His poster won the second prize in the theme Swasth Bharat. November 7, 2019

AWARD

November 7, 2019

Best Poster Prize to B.S. Karthikeyan at Society of Biological Chemists (SBCI) 2019

Society of Biological Chemists (India), BARC Mumbai

B.S. Karthikeyan, Research Associate in the group, presented a poster on our work on endocrine disruptors at SBCI 2019 organised by Bhabha Atomic Research Centre (BARC), Mumbai. His poster was adjudged to be the best poster at the meeting.

AWARD

November 3, 2019

Database of endocrine disruptors focuses on experimental evidence

By K.V. Venkatasubramanian in C&EN

Analysis of substances suggests no correlation between chemical structure and biological effects.

MEDIA COVERAGE

August 14, 2019

Indian team identifies hundreds of potential EDCs

By Emma Davies in ChemicalWatch

Researchers identified 686 potential endocrine disrupting chemicals from literature analysis.

MEDIA COVERAGE

July 25, 2019

Indian scientists develop database of everyday harmful to human health

By Dinesh C Sharma in Indian Science Wire

In our daily lives, we get exposed to dozens of chemicals either through products we use or consume as well as through exposure to the environment. Such chemicals are present in consumer products, pesticides and insecticides, cosmetics, drugs.

MEDIA COVERAGE

July 19, 2019

Now, a database of harmful chemicals in everyday items

By Snehal Fernandes in Hindustan Times

Ingredients in your everyday items may have an adverse effect on your body. Chennai-based Institute of Mathematical Sciences (IMSc) has created an online database — Database of Endocrine Disrupting Chemicals.

MEDIA COVERAGE

July 18, 2019