ASLab · Computational Biology · IMSc Chennai
We study complex biological systems through the lens of computation, mathematics, and data. Our work brings together large-scale biological data curation, network and systems modelling, topology, and computational analysis to investigate questions ranging from environmental exposures and One Health to natural products, gene regulation, metabolism, and microbial systems. Across these diverse problems, we develop computational resources and mathematical approaches that reveal patterns, mechanisms, and connections within biology.
I was born in Cuttack, Odisha, India and spent my first 7 years in a small industrial township Joda in Odisha. With my parents, I then moved to Kodarma in Jharkhand (formerly Bihar) for 2 years. In 1989, I moved to Delhi with my parents and settled there for next 20 years. In Delhi, I completed my Schooling, Bachelors, Masters and PhD. In May 2008, I moved to Leipzig, Germany for my Postdoctoral work. In March 2010, I shifted my base to Orsay (suburb of Paris). Between, March 2010 and February 2012, I kept shuttling between Paris and Leipzig. In February 2012, I moved to Seattle, USA. In March 2013, I moved to Trieste, Italy to continue my research. I returned to India in 2014.
Featured in The Hindu BusinessLine
AgingHallmarksDB brings together 3,111 genes associated with the 11 hallmarks of ageing in an integrated resource, helping researchers explore how the biological processes underlying ageing are connected.
MEDIA COVERAGEOctober 19, 2026
Featured in The Hindu – Science
Researchers from institutes in Chennai and Mumbai have developed AgingHallmarksDB, a free database that brings together 3,111 genes associated with the 11 major hallmarks of ageing. The platform helps researchers and the public visualise how these complex biological processes connect.
MEDIA COVERAGEOctober 18, 2026
By Beatrice Stafford in Scienmag
AgingHallmarksDB integrates 3,111 aging-associated genes across the 11 hallmarks of aging, providing a systems-level resource to study hallmark relationships, disease associations and aging biology.
MEDIA COVERAGEOctober 7, 2026
Shreyes Madgaonkar, along with our collaborator from NCCR, Chennai, Krishna Venkatarama Sharma, participated in a Q&A for Cell Reports Sustainability discussing our recently published work on chemicals used in aquaculture.
MEDIA COVERAGEOctober 2, 2026
By U Tejonmayam in The Times of India
ReCAnt (Resource on Chemicals used in Aquaculture and their Ecotoxicity), developed at the Institute of Mathematical Sciences (IMSc), in collaboration with the National Centre for Coastal Research (NCR), brings together information on 690 chemicals reported in aquaculture.
MEDIA COVERAGESeptember 19, 2026
SRM Institute of Science and Technology, Tamil Nadu, India
First Prize for Oral Presentation at the Indian Conference on Bioinformatics and Computaional Biology (IndiBioCom) - 2026, SRM Institute of Science and Technology.
AWARDSeptember 9, 2026
By Sahana Ghosh in Nature India
A new database finds agencies document only a fraction of the chemicals used in aquaculture globally.
MEDIA COVERAGEAugust 18, 2026
By Manupriya in IIT Madras Shaastra
A new study, published in Cell Reports Sustainability, describes a database that compiles 690 such chemicals used globally. Called ReCAnt (Resource on Chemicals used in Aquaculture and their Ecotoxicity), the database was developed by The Institute of Mathematical Sciences (IMSc) and the National Centre for Coastal Research, both based in Chennai.
MEDIA COVERAGEAugust 17, 2026
IISc, Bengaluru, India
Best Poster Award at the RISE for Healthy Aging conference, Indian Institute of Science, Bengaluru.
AWARDAugust 6-7, 2026
Jaisubasri Karthikeyan was awarded Best Project Award at the PSG Tech Alumni Association Annual General Body Meeting 2026, Coimbatore, for the co-first-authored publication "Benchmarking Artificial Intelligence Models for Predicting Nuclear Receptor Activity from Tox21 Assays", based on research conducted at IMSc, Chennai.
AWARDJuly 2, 2026
Madhumita Mondal received a full travel award to deliver a talk at the 2nd Bonn Conference on Mathematical Life Sciences (BCMLS), University of Bonn, Germany.
AWARDMarch 16-19, 2026,
By K Bharat Kumar in The Hindu Business Line
A computational approach to decoding ayurvedic medicine
MEDIA COVERAGEMarch 9, 2026
CSIR-NIO, Goa, India
Shreyes Rajan Madgaonkar was awarded Best Poster Prize under the theme "Ocean Health" at the World Ocean Science Congress (WOSC) - 2026, CSIR-NIO.
AWARDFebruary 26, 2026
Apple Podcasts
This research study utilizes topological data analysis (TDA) to examine how brain functional connectivity changes during healthy aging and in individuals with autism spectrum disorder (ASD).
PAPER TALKFebruary 7, 2026
By Sahana Ghosh in Nature India
A mathematical tool offers a closer look at brain architecture for improved therapies
MEDIA COVERAGEJanuary 22, 2026
By Jana Gregor in Max Planck Society News
Introduces a novel mathematical approach that enables identification of specific brain regions whose connectivity shifts with age or differs in autism spectrum disorder (ASD).
MEDIA COVERAGEJanuary 6, 2026
By Sahana Ghosh in Nature India
Researchers warn of a “Trojan horse” effect as plastic particles small enough to inhale carry carcinogens and microbes into the lungs.
MEDIA COVERAGENovember 12, 2025
Ajaya Kumar Sahoo received the HBNI Outstanding Doctoral Student Award 2025 in Life Sciences across HBNI CIs, for his PhD research.
AWARDJune 2, 2025
By Bharti Dharapuram in IMSc Newsletter March, 2025
MEDIA COVERAGEMay 30, 2025
By U Tejonmayam in The Times of India
MEDIA COVERAGEMay, 2025
By Bharti Dharapuram in IMSc Newsletter March, 2025
MEDIA COVERAGEMarch, 2025
Priyotosh Sil received a Flash Talk award of ₹5,000 at IBS 2025 hosted by IIT Madras, Chennai.
AWARDMarch 9, 2025
IISER Kolkata, India
Shreyes Rajan Madgaonkar was awarded Best Poster Prize at the International Conference on Microplastic Research Innovation & Sustainable Management (MPRISM), IISER Kolkata.
AWARDFebruary 16, 2025
By Subha Priyadarshini in Nature India
Mathematical approaches to identify health risks from plastic materials and compounds.
MEDIA COVERAGEJanuary, 2025
Toledo, Spain
Priyotosh Sil received a €350 travel award to attend the European Conference on Mathematical and Theoretical Biology, Toledo, Spain.
AWARDJuly 26, 2024
Université Paris-Saclay, France
Priyotosh Sil was awarded by IFCPAR/CEFIPRA to visit Université Paris-Saclay, France, for 3 months.
AWARDMay, 2024
Pondicherry University, India
Shanmuga Priya B was awarded Best Poster Prize at the International Conference on Bioinformatics in Health and Food Security (ICB-HFS), Pondicherry University.
AWARDFebruary 16, 2024
Faridabad, India
Nikhil Chivukula was awarded Best Poster Prize at the 17th Annual International Biocuration Conference (AIBC), Faridabad, India.
AWARDMarch 8, 2024
Janani R received the HBNI Outstanding Doctoral Student Award 2023 in Life Sciences across all HBNI CIs, for her PhD research.
AWARDJune 3, 2023
IISER Pune, India
Yasharth Yadav won Best Poster Prize at the Conference on Nonlinear Systems and Dynamics (CNSD), IISER Pune, with €200 prize and open-access publication invitation from EuroPhysics Letters.
AWARDDecember 18, 2022
By Shubashree Desikan in The Hindu October 2, 2022
MEDIA COVERAGEOctober 2, 2022
Ajaya Kumar Sahoo was awarded the Best Poster Prize at the HBNI Theme Meeting on Life Sciences, held at RRCAT, Indore.
AWARDSeptember 10, 2022
IIT Madras Shaastra Magazine
By MANUPRIYA in IIT Madras Shaastra Magazine May, 2022
MEDIA COVERAGEMay, 2022
ANSES, France
French Agency for Food, Environmental and Occupational Health & Safety (ANSES), as part of the second national strategy on endocrine disruptors (SNPE2) of France, has relied on our methodology and resource DEDuCT to establish a list of substances of interest.
By ANSES in Accelerating the assessment of endocrine disruptors April 15, 2021
POLICYApril 15, 2021
By Emma Davies ChemicalWatch
Indian researchers have updated and expanded a database of scientific studies on endocrine disrupting chemicals (EDCs), which was developed primarily as a tool to aid regulatory risk assessment. By Emma Davies in ChemicalWatch December 8, 2020
MEDIA COVERAGEDecember 8, 2020
India International Science Festival, Kolkata
B.S. Karthikeyan, Research Associate in the group, presented a poster on our work on endocrine disruptors at the Young Scientists Conference (YSC), IISF 2019 held in Kolkata. His poster won the second prize in the theme Swasth Bharat. November 7, 2019
AWARDNovember 7, 2019
Society of Biological Chemists (India), BARC Mumbai
B.S. Karthikeyan, Research Associate in the group, presented a poster on our work on endocrine disruptors at SBCI 2019 organised by Bhabha Atomic Research Centre (BARC), Mumbai. His poster was adjudged to be the best poster at the meeting.
AWARDNovember 3, 2019
By K.V. Venkatasubramanian in C&EN
Analysis of substances suggests no correlation between chemical structure and biological effects.
MEDIA COVERAGEAugust 14, 2019
By Emma Davies in ChemicalWatch
Researchers identified 686 potential endocrine disrupting chemicals from literature analysis.
MEDIA COVERAGEJuly 25, 2019
By Dinesh C Sharma in Indian Science Wire
In our daily lives, we get exposed to dozens of chemicals either through products we use or consume as well as through exposure to the environment. Such chemicals are present in consumer products, pesticides and insecticides, cosmetics, drugs.
MEDIA COVERAGEJuly 19, 2019
By Snehal Fernandes in Hindustan Times
Ingredients in your everyday items may have an adverse effect on your body. Chennai-based Institute of Mathematical Sciences (IMSc) has created an online database — Database of Endocrine Disrupting Chemicals.
MEDIA COVERAGEJuly 18, 2019